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In rats with renovascular hypertension, HS inhibits the AngII-ATR signaling axis, downregulates myocardial ATR expression and AngII levels, while enhancing SOD activity and reducing ROS accumulation, creating a synergistic antioxidant-RAAS inhibitory effect (Liu et al., 2017)
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Local BPC-157 near an injury combined with systemic TB-500 elsewhere enables targeted delivery without mixing constraints
This dual engagement may explain why BPC-157 appears to promote not just collagen deposition but organised collagen deposition: the FAK-paxillin axis coordinates cytoskeletal tension, and cells under appropriate cytoskeletal tension deposit collagen with directional preference aligned to the local force field
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