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Disulfide-linked polymerdrug conjugates and nanocarriers engineered for GSH-triggered drug release have shown favorable safety and preliminary efficacy profiles, highlighting the feasibility of translating redox-responsive strategies into clinical practice [120]

ScharfsteinJSKeaneyJFJr.SlivkaAWelchGNVitaJAStamlerJSet alIn vivo transfer of nitric oxide between a plasma protein-bound reservoir and low-molecular weight thiols

During oxidative stress, ROS directly interact with amino acid side chains (mainly lysine, arginine, proline, and threonine), or peptide bonds in the polypeptide chain are broken and carbonyl groups are formed inside the polypeptide structure (168)

Am J Psychiatry