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Glial cells and neurons maintain dynamic communication via signaling molecules (cytokines, neurotransmitters, ROS, NO, glutamate) and extracellular vesicles containing proteins, mRNA, and miRNA

The NRF2-dependent effect was identified through the antioxidative response element in target gene loci, while NRF2-independent effects act through DNA 5hmC modifications via the regulation of the metabolite L2HG

When the benefit outweighs the side effect, and when it might not For most patients, the metabolic benefits of GLP-1 therapy, including improved cardiovascular risk factors, better insulin sensitivity, reduced visceral fat, and meaningful weight loss, far outweigh a temporary or modest change in libido

3-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H 2 S 2 , H 2 S 3 and H 2 S