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However, these modifications must be balanced against potential effects on biological activity and safety
El GCLC constituye toda la actividad enzimtica, mientras que la GCLM aumenta la eficiencia cataltica del GCLC
Song et al showed that decreasing periplasmic GSH by deleting the GSH exporter CydD triggers the CpxR/SoxS two-component systems, upregulating the AcrAB-TolC pump and lowering intracellular drug accumulation
Most patients notice appetite suppression within the first few weeks, but significant weight loss typically takes 3 to 6 months to become clearly measurable
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