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Recent single-cell RNA-seq studies have revealed substantial transcriptional heterogeneity among microglia in homeostasis and disease [80,81,82]
instead you notice that your hair looks thinner and less dense overall
Without shelterin, exposed telomeric DNA triggers ATM/ATR kinase cascades, p53 activation, and irreversible senescence the same outcome produced by critically short telomeres that can no longer support proper shelterin assembly
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