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Heterogeneity of Renal Endpoints and Implications A major source of heterogeneity across the evidence base relates to the definition and reporting of renal outcomes

Those who were already treated with an additional glucose-lowering drug (or several) at the beginning of combination therapy were included if (and when) the additional medication was halted and the individual thus received only a combination of metformin and GLP-1 RA or metformin and DPP-4i treatment

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So, heres insight into why this is the case and the variables that tend to make the biggest difference