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Hormonal changes: GLP-1 receptor stimulation on ADSCs indirectly reduces estrogen production from dermal white adipose tissue (DWAT), which decreases fibroblast stimulation to produce collagen

GLP-1 (Glucagon-Like Peptide-1) This is the same pathway targeted by: Wegovy (semaglutide) Ozempic (semaglutide) Saxenda (liraglutide) GLP-1 helps by: slowing stomach emptying increasing feelings of fullness reducing hunger lowering food cravings improving insulin release after meals helping regulate blood sugar 2

Levels can be increased by systemic administration and concentrate in the seminal plasma, where it can produce its physiologic and therapeutic roles

Luteolin also attenuated pro-inflammatory mediators such as IL-6, TNF-, and NF-B and reduced myofibroblast activation (-SMA), consistent with inhibition of fibrotic remodeling and restoration of redox homeostasis