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The 50100mg daily dose range was derived from rodent models where 10mg/kg bodyweight produced measurable NNMT suppression without toxicity across 12-week administration periods
The amount of water you add directly determines your concentration
Scientific References: Gwyer D, Wragg NM, Wilson SL., Cell and Tissue Research , 2019
One of the possible reasons that anaemia is much less prominent in B12 deficiency than lets say 30 years ago, is that many countries have started mandatory fortification of food with folate
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