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GLP-1 Side Effects at a Glance Nausea & vomiting Constipation Diarrhea Reflux & sulfur burps Loss of muscle and lean mass Skin, hair, and nail changes Fatigue, depression, and the blahs Dehydration Less Common but Serious Side Effects Pancreatitis and pancreatic cancer Gallstones & gallbladder disease Thyroid cancer Acute kidney injury Retinopathy, macular degeneration, and nonarteritic anterior ischemic optic neuropathy (NAION) Common GLP-1 Side Effects and How to Manage Them Most side effects show up early, often within the first few days of beginning GLP-1 treatment

GLP-1 receptor agonists slow gastric emptying, which may cause stomach contents to remain present longer than expected despite appropriate fasting

TRIUMPH-1 (NCT05929066, n=2,339, 80 weeks, general obesity): 28.3% average weight loss on the 12mg dose

Lingvay I, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, Hardt-Lindberg S, Hovingh GK, Kahn SE, Kushner RF, et al