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By the time celebrity adoption pushed the brand name into the cultural bloodstream, the underlying medicine had already done the harder work

In rare cases (less than 1%) patients may have serious side effects like gallstones or pancreatitis, and some doctors say more research is needed to help determine the long-term effects on a still-developing brain

In a 2017 systematic review of 18 trials, including 1,143 subjects with rheumatoid arthritis, only 4 of 18 placebo-controlled trials showed a benefit of omega-3 PUFA supplementation (2.2-3.6 g/day for 12-36 weeks) on pain level reported by patients and/or assessed by physicians (158)

Prioritizing individuals with SMIs within fair allocation frameworks may help reduce excess and premature mortality in this vulnerable population in the near term