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Microsomal GSTs are structurally distinct from the cytosolic in that they homo- and heterotrimerize rather than dimerize to form a single active site
Mol Metab 2017;6:4406.ArticlePubMedPMC 60
For instance, IGF-1 is made in the liver, hence an undiagnosed precancerous liver disease could have prevented the liver from producing normal levels of IGF-1. The study demonstrates the power of using population-level approaches to assess the extent to which risk factors apply across the entire cancer spectrum
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