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We just dont know the answer to that, Angadi said

Arun Chhokar, University of Delhi, India

Katsuyoshi Takata and Professor Tadashi Yoshino, Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences for providing samples for immunostaining

This leads to the formation of regenerative hepatic nodules encased in dense fibrous tissue, containing significantly higher levels of extracellular matrix proteins, particularly collagen types I, III, and IV, which hinder portal blood flow and elevate portal pressure, ultimately culminating in clinically significant portal hypertension in later disease stages ( In this comprehensive and evidence-driven review, the objective is to scrutinize the repercussions, diagnosis, and management of these often overlooked yet prevalent and challenging-to-treat symptoms encountered in cirrhosis (Figure 1)