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GLP-1 is an endogenous incretin hormone that enhances glucose-dependent insulin secretion following nutrient ingestion

Graphical abstract Similar content being viewed by others Introduction Diabetic neuropathy (DN) is one of the most frequent chronic complications of diabetes mellitus which occurs in a later stage (Chen and Song 2024) and involves both peripheral and central nerves, particularly the former, known as DPN (Diabetic Peripheral Neuropathy), which affects about one-third of patients with diabetes

Accordingly, in the context of LPS, IFN treatment exclusively led to iNOS + macrophages and simultaneous GM-CSF and IFN treatment led to ARG1 + iNOS + macrophages, whereas GM-CSF treatment alone mainly induced ARG1 + iNOS macrophages that engaged in arginine catabolism

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