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Keywords: type 2 diabetes, incretins, glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide Introduction: The Incretin Effect in Health and Disease The gastrointestinal system has an intricate pathway of hormones that are released from the gut lining upon ingestion of food and regulate glucose metabolism and appetite

[14] [15] Semaglutide may be used as monotherapy or in combination with other antidiabetic medications, including metformin, sulfonylureas, sodium-glucose cotransporter-2 (SGLT2) inhibitors, and insulin

On a test that measured changes in clinical dementia before and after treatment, there was no difference between the drug and the placebo