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Fourth, observational studies remain susceptible to residual confounding and treatment-selection bias despite statistical adjustment

PIONEER 4 PIONEER 4 was an important trial comparing the addition of oral semaglutide or liraglutide to background metformin with or without an SGLT-2 inhibitor in patients with T2DM

Back Knudsen, LB, Nielsen, PF, Huusfeldt, PO, et al (2000) 'Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration', Journal of Medicinal Chemistry , 43, 1664-69

If you are losing weight rapidly, ask your provider about muscle protection strategies, including adequate protein and resistance training