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Receptor activation triggers a phospholipase C cascade, intracellular calcium mobilisation, and downstream stimulation of growth hormone secretion
Additionally, the mean HbA1c reduction with survodutide at a dose of 0.9 mg was similar to that observed with semaglutide
Cell sorting was performed using a BD FACSAria III cell sorter, whilst flow cytometric analysis was performed on a BD FACSCanto II
So this is a growing threat that I think needs to be monitored closely. If GLP-1s do become prohibited, athletes could theoretically apply for a therapeutic use exemption (TUE), which allows them to take a drug if it is treating a legitimate medical condition, and does not meaningfully enhance their performance
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