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Paninfluenza A/B monoclonal nAbs, such as the HA-stem targeting CR9114, have shown protection in lethal heterosubtypic influenza challenge models

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TRIUMPH-2 and TRIUMPH-3 covering more complex populations with diabetes and cardiovascular disease showed lower efficacy (20.8% and 22.6% respectively), reflecting the impact of comorbidities rather than any inconsistency in the drug's effect

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