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171 Certain mutations of the methylenetetrahydrofolate reductase ( MTHFR ) gene are known to cause abnormal homocysteine metabolism, resulting in high homocysteine levels, and some studies have found these mutations may be more common in women with infertility

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Out of the 36 metabolic pathways that showed significant changes in metabolic activity in response to the GDH2 gene deletion when cells were cultured in MM medium, all except phosphonate and phosphinate metabolism were upregulated (Fig

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