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As a result, lifestyle interventions alone, such as diet and exercise, are often insufficient, and effective management typically requires a combination of strategies to address the underlying biology of obesity. The group explored data from more than 60,000 patients who originally participated in one of 56 randomized controlled trials (RCTs)
Drucker, Glucagon-like Peptide-1 Receptor-based Therapeutics for Metabolic Liver Disease, Endocrine Reviews, 2023, 44, 1432
GLP-1 has a variety of physiological functions, which can regulate blood glucose level by promoting insulin secretion and synthesis, stimulating -cell proliferation and inducing islet regeneration, inhibiting -cell apoptosis and glucagon release, delaying gastric emptying and controlling appetite (Mller et al., 2019
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