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The most cited single result is from Yun and colleagues in 2018, who showed that NLY01, a long-acting PEGylated GLP-1R agonist, blocked the microglia-driven conversion of resting astrocytes into the neurotoxic A1 phenotype in mouse models, a process implicated in neuronal death in both Parkinsons and Alzheimers disease [4]
10.1038/s41591-021-01418-2 155 SlootY
The microbes go to work
Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase
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