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Hypothetically, this may be due either to an insufficient induction of the primary immune response during acute infection or to the inability to maintain the T-cell response at high levels during chronic hepatitis C

High levels of ELOVL5 have been found in mesenchymal-type gastric cancer cells (GCs), where they can increase the generation of arachidonic acid (AA) and adrenic acid (AdA), thus sensitizing tumor cells to ferroptosis [98]

The catch: most oral glutathione breaks down in digestion before it reaches the cells

But it does mean you're accepting risks that don't exist with topical application, for benefits that may not be meaningfully greater