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If you're taking a GLP-1 and notice symptoms such as fatigue, dizziness, or dry mouth, dehydration may be one possible cause

While early findings are promising, more research is needed to understand the long-term effects when GLP-1s are used with other treatments (4,5)

Exogenous melatonin has acute sleepiness-inducing and temperature-lowering effects during 'biological daytime', and when suitably timed (it is most effective around dusk and dawn), it will shift the phase of the human circadian clock (sleep, endogenous melatonin, core body temperature, cortisol) to earlier (advance phase shift) or later (delay phase shift) times