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The pineal gland also produces several bioactive peptides and neurotransmitters that influence everything from immune function to reproductive hormones to oxidative stress defense

Studies have observed decreased cyclooxygenase-2 (COX-2) gene expression, reduced myeloperoxidase activity, and lower levels of pro-inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-)