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While this partial reduction in cholesterol levels appears beneficial for beta cell GLP-1R function, we previously observed that a much more drastic cholesterol extraction using MCD leads to the opposite effect, inhibiting agonist-induced GLP-1R cAMP responses (25), a result that we hypothesise is linked to the profound disruption of plasma membrane architecture caused by MCD (47)
J Ethnopharmacol 106, 353359, 10.1016/j.jep.2006.01.010 (2006)
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