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HRD1 inhibitors Pharmacological inhibition of HRD1, a negative regulator of NRF2 implicated in its ubiquitination and degradation, was tested in human liver tissues and in an animal model for the liver cirrhosis characterized by increased ER stress and ROS: LS-102 alleviated liver cirrhosis enhancing NRF2 signalling pathway [228]
Wang YT, Shen RX, Xing D, Zhao CP, Gao HT, Wu JH, Zhang N, Zhang HD, Chen Y, Zhao TY, Li CX (2021) Metagenome sequencing reveals the midgut microbiota makeup of Culex pipiens quinquefasciatus and its possible relationship with insecticide resistance
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