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Finally, the blood concentration of GSH remains completely stable despite the large transient amino acid input fluctuations

Moreover, microsomal metabolism studies demonstrated that Dihexa had very low phase I metabolism, with an average intrinsic clearance of 2.72 l/min/mg and a half-life of 509.4 minutes

This is also in agreement with other studies reporting amplified sartan-induced thermal fluctuations that uncouple the bilayer stacks [304, 305], most likely due to a softening of the membrane as expected from the reduction in the area per lipid

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