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Risk of bias was assessed using the Cochrane Risk of Bias 2 (ROB2) tool across five domains [30]
Alterations in Vd resulting from reduced fat mass and alterations in clearance resulting from changes in CYP activity and GFR are key factors in determining pharmacokinetics
FASEB J 2004
Since 1978, when ELISA was first described [2], it became the gold standard antigen-antibody detection assay in basic research of which some assays were further optimized for diagnostic purposes and became commercially available
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