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Of more than 100 compounds synthesized and tested for TGR inhibition (a more thorough description of compound design will form the basis of a future manuscript), the most promising were selected to be extensively characterized in the in vitro and in vivo studies described below
The ability to purify protein complexes enables detailed analysis of their functional roles and interactions within the cell
Int J Biol Macromol 45:372376
These adaptations occurred despite decreased islet CL levels and lipid profile alterations, indicating compensatory changes in islet cell composition, mitochondrial morphology and metabolism that preserved islet function
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