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Outcomes observed in clinical trials may not reflect future realworld use

IGF1 is a primary mediator of GH activity and directly influences muscle hypertrophy, protein synthesis, and nutrient partitioning (Yakar et al., Endocrinology )

However, in this case, the patients usually do not show symptoms of metabolic acidosis or hemolytic anemia, and antioxidant therapies are ineffective ( Table 2 Clinical features and laboratory data corresponding to patients diagnosed with GSSD in China

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