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The reactive oxygen species (ROS) is able to induce the proliferation of leiomyoma smooth muscle cells and it is also necessary for triggering the MAPK1/MAPK3 signaling pathway, which contributes to leiomyoma smooth muscle cell proliferation (Mesquita et al., 2010)

Although there is no official recommendation for daily glutathione intake, it is recognized that levels should be sufficiently high to maintain optimal bodily functions and protect against age-related diseases and environmental stress

5 Challenges and future directions Despite compelling mechanistic insights and promising early-phase interventions, there are several challenges in translating perioperative mitochondrial immunomodulation into standard clinical care: 5.1 Timing and deliverability Many mitochondrial-protective strategies are highly time-sensitive

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