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Materials and Methods Reagents Staurosporine was purchased from MilliporeSigma (Billerica, MA)

All in vitro studies combined tissue from both sexes, since: 1) no sex-specific phenotype was observed in vivo

It has been shown that p38 MAPK, c-fos (Zhang et al., 2021) and TNF- (Zheng et al., 2023b) are all involved in the inflammatory response, and they are widely associated with the pathogenesis of inflammatory diseases, serving a key role in regulating the inflammatory immune process

Acanthosis nigricans symptoms you need to watch out for are slowly developing black, velvety patches of skin most commonly appearing in skin creases