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Ultimately, the understanding of systemic and brain PK of 7,8-DHF among neonatal mice could be applied to larger animal models of neonatal HIE especially the ones that show the kidney and liver injury phenotype that is not present in Vannuccis neonatal rodent model of HI

One possibility is that GSH reduction is particularly pronounced in the thalamus due to its central role in nociceptive processing and pain transmission, as discussed below

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