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anti-fibrotic effects via PPAR upregulation followed by TGF-, CTGF, and PDGF downregulation

One study covered in the review found that a topical containing Syn-Ake resulted in a 52% reduction in wrinkle size after 28 days of use.34 (As an interesting side note, you may have noticed that Syn-Ake kind of looks or sounds like the word snake. This is because the synthetic peptide Syn-Ake is an analog of a natural one called Waglerin-1, which is derived from the venom of the Southeast Asian temple viper.)34 As with Allies of Skin, much of the research behind the ingredients in The Ordinarys product is positive

The best choice depends on your goals

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