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Specifically, miR-34b, miR-326, miR-432, miR-548c-3p, miR-570, and miR-603, were found to be down-regulated in GH secreting adenomas leading to increased mRNA and protein levels of their target genes including High Mobility Group AT-Hook 1 (HMGA1), High Mobility Group AT-Hook 2 (HMGA2), and E2F Transcription Factor 1 (E2F1) (52)
Pickart and colleagues documented that GHK-Cu influences the expression of over 4,000 human genes, with significant upregulation of genes involved in collagen synthesis, DNA repair, and antioxidant defense [1]
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