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MOTS-c is frequently explored in research models evaluating mitochondrial-nuclear signaling communication, energy-related signaling balance, and cellular resilience mechanisms in metabolically active tissues
In particular, they pointed out that although NRF2 has been traditionally considered as a tumor suppressor because of its cytoprotective functions [320], a growing number of studies have shown a strong NRF2 activation at certain stages of cancer [318, 321]
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One recent paper found nearly 39,000 cardiovascular events were avoided when patients had access to obesity treatment, along with improvements in chronic kidney and liver diseases
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