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Oral routes are associated with delayed or inconsistent systemic effects, depending on molecular size, chemical modification, and formulation

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Greater weight loss efficacy of tirzepatide 10 mg ( 3.2 kg) and 15 mg ( 5.2 kg) compared to semaglutide was also observed in an indirect comparison with data from the SUSTAIN FORTE study, where semaglutide was administered at the maximum hypoglycemic dose of 2.0 mg [49]