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This makes it particularly harmful because it: delivers fatty acids directly to the liver worsens liver insulin resistance drives inflammation drives up sdLDL that cannot easily be removed by LDL receptors (and is principle cause of coronary artery disease) accelerates cardiovascular disease Visceral fat becomes both a marker of metabolic overload and a driver of further damage

It is also not recommended during breastfeeding

however, this effect is not mediated via the 5-HT 3 receptor, as inhibition of the receptor does not alter the response

they differ from person to person, based on individual health goals and metabolic responses