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Long-term efficacy of metformin in overweight-obese pcos: longitudinal follow-up of retrospective cohort

4 weeks (300500 mcg/day): ~12 vials 8 weeks (300500 mcg/day): ~23 vials Advanced (500750 mcg, 2/day): more vials needed Insulin Syringes (U-100, 1 mL) Per injection: 1 syringe 8 weeks (once daily): ~56 syringes 8 weeks (twice daily): ~112 syringes Bacteriostatic Water (10 mL bottles) Use 3.0 mL (gradual) or 2.0 mL (advanced) per 10 mg vial for reconstitution

It is an essential part of the protocol that determines long-term success