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The off-window is part of the protocol continuous indefinite use is not supported by the component research

Regul Pept 137(3):168172 Vrang N, Larsen PJ (2010) Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides

10.1016/0026-0495(67)90083-2 339 WenS

Administration of anti-hepatic encephalopathy drugs such as neomycin, lactulose, lactitol, branched chain amino acids, and rifaximin was permitted when the patients were already taking these drugs before the study, but we forbade starting the administration of these drugs during the study