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Most patients return to non-strenuous work within 24 days

Contraindications to tranexamic acid History of coronary stent(s) History of active hematuria (it is thought that administration of TXA in the patient with hematuria may cause a clot resulting in obstructive uropathy) History of venous thromboembolic disease Update 2020 : An international randomized placebo-controlled trial involving 12,009 patients examined the role of tranexamic acid in acute gastrointestinal bleeding, with primary outcomes including death within 5 days and thromboembolic events

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Additionally, GLP-1RAs ameliorate DPN through various mechanisms, including the inhibition of inflammation, oxidative stress, and extracellular matrix remodeling, while simultaneously improving neural structure, function, and energy metabolism [11, 12, 30, 79,80,81,82,83,84,85,86]