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AVAILABILITY OF DATA All data not contained either in this manuscript or elsewhere in the published literature (e.g., microsphere quantification, raw pressure-volume loop tracings, raw proteomic values, etc.) but that are germane to the full evaluation of results are fully available upon request made to the corresponding author

Document possible confounders beside adverse observations: Site irritation, for example, should be recorded along with concentration, injection location, and preparation details

For instance, semaglutide, a novel GLP-1RA, has demonstrated promise in ameliorating EAE-induced cognitive and physical dysfunction in mice

Moreover, we successfully identified the upstream regulators governing these genes and the associated disorders, denoted in blue for upregulation and orange for downregulation