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This study utilized a CASSCF approach to demonstrate that while all forms of vitamin B12 interact with glutathione, NADPH, FMN, and FAD by breaking Co-C or Co-O bonds and facilitating electron transfer, only glutathione effectively converts cyanocobalamin into a biologically active form, aligning with clinical observations

The ensuing mechanistic study revealed that ebselen protected cells and mice models by lowering radiation-induced ROS production, followed by inhibition of lipid peroxidation, protein carbonylation, DNA damage, and ultimately apoptosis