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The STEP programme showed a weight loss of up to 16.9% after one year of treatment with SEMA 2.4 mg, mainly at the expense of fat mass (difference versus placebo: fat mass 3.29%

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Todays market leaders include semaglutide (branded as Ozempic for diabetes and Wegovy for weight management) and tirzepatide (branded as Mounjaro for diabetes and Zepbound for weight management)