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The research and development of new pharmaceuticals is increasingly an international affair, something that recent discussion about how tariffs might affect drug prices has made very clear

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We now have a breakthrough class of drugs that can achieve profound weight loss equivalent to bariatric surgery, along with the side benefits of reducing cardiovascular risk factors (hypertension and hyperlipidemia), improving glucose regulation, reversing fatty liver, and the many detrimental long-term effects of obesity such as osteoarthritis and various cancers

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Otherwise, serious adverse events were reported in ~6% of participants and were evenly distributed across tirzepatide and placebo groups

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