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Common signs include: Fatigue and weakness Neurological changes, such as numbness or tingling in the hands and feet Megaloblastic anemia, characterized by large, abnormal red blood cells Cognitive difficulties, including memory loss and confusion Early detection and treatment of B12 deficiency can make a big difference
In mitochondria [edit] The metabolism of propionyl-CoA occurs in the mitochondria and requires Vitamin B 12 (as adenosylcobalamin) to make succinyl-CoA
Metabolic Rewiring: By stopping the conversion of nicotinamide (NAM) into 1-methylnicotinamide (1-MNA), the cell is forced to recycle NAM into NAD+
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