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Acknowledgements The authors would like to acknowledge the technical assistance of staff in the Biological Services Unit at the University of Sheffield and the Sheffield Institute for Translational Neuroscience, particularly Ian Coldicott

Severe gastrointestinal conditions: Those with delayed gastric emptying, gastroparesis, or chronic GI dysmotility may experience exacerbated symptoms due to the drugs action on gastric motility

Sessions are brief and efficient, with IV lounge variants (approximately 30 minutes) offering enhanced nutrient absorption for faster, more noticeable effects

If you have sensitive skin, test the patch on a small area first