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increased lipid metabolism, VO2max, oxygen consumption, and L-carnitine plasma concentrations

However, one of the most important limitations is heterogeneity of the study populations, including disease type, tolerance to treatment, dose of DHA and EPA, timing and duration of DHA and EPA supply, EPA to DHA ratio, initial EPA and DHA status, intake of other nutrients such as vitamins, clinical status, and concomitant use with medications

Functional and phenotypic analyses confirm the induction of a pancreatic endocrine fate, including positive dithizone (DTZ) staining indicative of insulin production, as well as the upregulation of key pancreatic markers such as paired box gene 4 (PAX4), neurogenin 3 (NGN3), Isl-1, Some protocols utilized additional strategies like fibrin encapsulation, decellularized amniotic membrane [52] or 3D alginate encapsulation [51] scaffolds to enhance differentiation efficiency and mimic physiological conditions more closely