It is one of the few research peptides with a direct path to FDA-approved clinical use afamelanotide received FDA approval in 2019 for the treatment of erythropoietic protoporphyria (EPP), a rare genetic photosensitivity disorder
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J Biol Chem 284:1072810736 Chepurny OG, Kelley GG, Dzhura I, Leech CA, Roe MW, Dzhura E, Li X, Schwede F, Genieser HG, Holz GG (2010) PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2-O-Me-cAMP-AM in human islets of Langerhans