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These neural pathways are relevant not only to eating behaviour but also to the use of addictive substances such as alcohol, opioids, nicotine and cocaine

Research suggests that exercise can improve appetite regulation, and some studies indicate that GLP-1 levels may increase following physical activity, particularly after moderate-to-vigorous exercise

The oral tirzepatide research shows that even complex peptide agonists can potentially be reformulated for oral delivery, suggesting the same may eventually be possible for retatrutide-class compounds