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Systemic elevation of PTEN induces a tumor-suppressive metabolic state

Our results provide a possible mechanism in which upregulation of phosphorylated p53 and p16 maintain the cell cycle arrest of keloid fibroblasts, and FOXO4-DRI selectively induces apoptosis of keloid senescent fibroblasts by prompting p53-pS15 nuclear exclusion

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In many APAC markets where healthcare spending is largely out of pocket, adoption tends to be slower, explains FMCG consultant Veena Giridhar-Gopal, adding that the demand profile has traditionally differed from that of western markets